Endocrine Abstracts

Background: Pancreatic neuroendocrine tumours (PanNETs) are an understudied cancer type characterised by frequent metastasis, clinical recurrence, and high mortality rate. PanNETs originate from pancreatic islets, primarily β cells, and comprise two molecular subtypes: poorly invasive, relatively benign islet tumour (IT) and highly aggressive metastasis-like primary (MLP) tumour. The MLP subtype arises from IT through a switch in cell fate involving the acquisition of neu...

Background: Neuroendocrine cancers arise in the endocrine cells localized throughout the body. Most are found in the Gastroenteropancreatic (GEP) system pancreas, stomach, and small and large intestines. They are heterogenous in their etiology, morphology, and phenotypes. Due to late diagnosis and low prevalence, clinical specimens are limited for research. Thus, preclinical models are pivotal for the understanding of this disease. This study focuses on establishing a novel pa...